解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Serum retinol and serum carotene concentrations were determined over a 6-month period in 137 outpatients with Crohn's disease. Serum retinol measurements were within the reference range for all patients at each assessment period, while serum carotene levels were low in about one quarter of the patients. Of the 56 pati...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199495
更新日期:1987-01-01 00:00:00
abstract::The effects of somatostatin on cholera toxin-induced secretory diarrhea and the appearance of glycoenzymes in the intestinal lumen and intestinal lymph were investigated in rat small intestine. After exposure to cholera toxin, marked fluid accumulation in the small intestinal tract and elevation of the jejunal mucosal...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199411
更新日期:1987-01-01 00:00:00
abstract::Hepatitis B surface antigen (HBsAg)-associated receptors for polymerized human serum albumin (RpHSA) are assumed to mediate viral attachment to hepatocytes in hepatitis B virus (HBV) infection. RpHSA was found to be coded by the pre-S region of HBV genome. Recently, the antiviral effect of recombinant leukocyte alpha-...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199474
更新日期:1987-01-01 00:00:00
abstract::The secretion of pancreatic polypeptide (PP) seems to be controlled by vagal cholinergic mechanisms, since both vagotomy and atropine significantly inhibit the PP response to food intake, sham feeding or insulin hypoglycaemia. In the present study, we examined the PP response to a meal after orthotopic autotransplanta...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199492
更新日期:1987-01-01 00:00:00
abstract::Indicators of net water movement are used in a variety of intestinal transport studies. Such indicators should be virtually unabsorbed under study conditions. The effects of stimuli that alter intestinal mass on indicator recovery have not been examined. We used the male albino rat to study the effects of food restric...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199576
更新日期:1987-01-01 00:00:00
abstract::The effect of the long-acting somatostatin analogue Sandostatin (SMS 201-995) on intestinal absorption and propagation (mouth-to-caecum transit time; MCTT), on pancreatic secretion and on gall bladder contraction after direct (secretin-pancreozymin test) and indirect stimulation (Lundh meal), and on meal-induced respo...
journal_title:Digestion
pub_type: 临床试验,杂志文章
doi:10.1159/000199408
更新日期:1987-01-01 00:00:00
abstract::The luminal mucus layer of the rat's small intestine was separated from the mucosa by filling the lumen with agar jelly. When the rats were fasted overnight and given 59Fe or 65Zn by stomach tube the mucus isolated by this technique contained more isotope and more sialic acid than fed controls, and more of the isotope...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199480
更新日期:1987-01-01 00:00:00
abstract::To assess the sensitivity, specificity and clinical value of prealbumin as liver test, prealbumin plasma levels were measured in 100 patients with liver disease and in 65 patients without clinical evidence of liver impairment. The sensitivity of prealbuminemia was higher than that of albumin, pseudocholinesterase, apo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199471
更新日期:1987-01-01 00:00:00
abstract::The effects of rioprostil (a newly developed synthetic prostaglandin E1 analogue) on meal-stimulated gastric acid secretion was evaluated in 8 healthy human volunteers. Gastric acid output was measured by intragastric titration on 4 different occasions. The following procedure was invariably employed: after a basal pe...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000199413
更新日期:1987-01-01 00:00:00
abstract::CCK-8, bombesin, secretin and urecholine added in various concentrations to the incubation medium of the dispersed pancreatic acini, obtained from rats, resulted in a dose-dependent stimulation of amylase secretion, the half-maximal response being achieved at 3 X 10(-12), 10(-10), 10(-7) and 10(-5) M, respectively. Pi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199415
更新日期:1987-01-01 00:00:00
abstract::We describe a patient with relapses of Clostridium difficile cytotoxin-positive pseudomembranous colitis (PMC) after treatment with vancomycin, a course of metronidazole and a trial of bacitracin. She remains free of disease after a prolonged course of cholestyramine. We suggest there may be a role for anion-exchange ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199299
更新日期:1986-01-01 00:00:00
abstract::Differential absorption of D-xylose and 3-O-methyl-D-glucose, and unmediated intestinal permeation of lactulose and L-rhamnose has been investigated in 14 patients with diarrhoea following tropical exposure and in 16 healthy control subjects. Five had malabsorption of fat, D-xylose and B12 ('tropical malabsorption' (T...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199282
更新日期:1986-01-01 00:00:00
abstract::The rates of intracellular transport of newly synthesized amylase, lipase, trypsinogen and chymotrypsinogen were compared in the anaesthesized rat pancreas by measuring their rates of secretion while keeping their relative rates of synthesis in a steady state. It is concluded that pancreatic proteins are not transport...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199327
更新日期:1986-01-01 00:00:00
abstract::The healing of acetic acid-induced gastric and duodenal ulcers was examined together with the biochemical indices of growth in gastric and duodenal mucosa in the following three groups of rats: (a) chow-fed, (b) fed an isocaloric liquid diet, (c) fed the liquid diet plus pentagastrin injections (250 micrograms/kg, 3 t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199280
更新日期:1986-01-01 00:00:00
abstract::There is no generally accepted treatment in the irritable bowel syndrome (IBS), probably because of a lack of convincing therapeutic trials. In the present study, 120 outpatients with IBS participated in a prospective randomized therapeutic trial. According to a double-blind design, 40 patients received 400 mg/day meb...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000199329
更新日期:1986-01-01 00:00:00
abstract::Mechanisms of antisecretory action of intragastric FPL-52694, a mast cell stabilizer, were investigated in anesthetized rats. In Schild's rat preparation, intravenous FPL-52694 (10 mg/kg) significantly suppressed acid secretion in response to only tetragastrin (20 micrograms/kg, i.v.) (42.1 +/- 19.4%), while intragast...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199339
更新日期:1986-01-01 00:00:00
abstract::Eighteen cases of severe hyperplasia of fundic argyrophil cells observed during routine histologic examination of endoscopic gastric biopsy specimens from unselected patients with upper gastro-intestinal symptomatology were investigated. All patients, except one, were female with a mean age of 57 years. Atrophic gastr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199389
更新日期:1986-01-01 00:00:00
abstract::The effect of the interruption of the enterohepatic circulation on bile production in anesthetized rats both before and after two thirds partial hepatectomy (PH) was studied. Both in the control animals and in the different periods after PH, interruption of the enterohepatic circulation led to significant decreases in...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199360
更新日期:1986-01-01 00:00:00
abstract::Different materials dissolved in 0.9% NaCl were injected into the connective, interlobular tissue of the duodenal part of the rat pancreas. Activated rat pancreatic juice or trypsin were able to induce localized necrohemorrhagic pancreatitis. Only mild edema and leukocytic infiltration were observed after injecting bo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199313
更新日期:1986-01-01 00:00:00
abstract::A highly significant increase in net fluxes across the guinea-pig small intestine for both 45Ca2+ and 35SO4(2-), in the presence of cystic fibrosis plasma compared with non-cystic fibrosis plasma, was observed (p less than 0.001). In the presence of cystic fibrosis plasma, the nuclear, mitochondrial, microsomal and so...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199307
更新日期:1986-01-01 00:00:00
abstract::The effects of secretin and caerulein on the absorption of water, sodium, potassium and glucose from the jejunum of dogs were investigated. Intravenous infusion of 1 clinical unit (CU; 82 pmol/kg/h) of secretin inhibited jejunal absorption of water, sodium and glucose compared to control period. Adding an intravenous ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199369
更新日期:1986-01-01 00:00:00
abstract::The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clear...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199357
更新日期:1986-01-01 00:00:00
abstract::The aim of the study was to define the effects of sex, age, smoking, alcohol, analgesic ingestion, and treatment method whereby healing was initially induced on the prognosis of patients with a chronic duodenal ulcer (DU). 122 patients were assessed 1 year after the endoscopic demonstration of a DU. Two outcome variab...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199171
更新日期:1985-01-01 00:00:00
abstract::A young woman with long-standing inflammatory bowel disease presented with a tender left gastrocnemius myositis in association with an exacerbation of her disease. Muscle biopsy showed a chronic inflammatory cell infiltrate and atrophic muscle fibres, but no granulomata or vasculitis, and her symptoms responded to hig...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199251
更新日期:1985-01-01 00:00:00
abstract::Rectal biopsies were maintained in organ culture over a 24-hour culture period, with good preservation of histological architecture. A filtrate containing Clostridium difficile toxin significantly inhibited the rise in epithelial alkaline phosphatase activity normally seen during culture. This effect was abolished by ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199212
更新日期:1985-01-01 00:00:00
abstract::23 cirrhotics with ascites and sodium retention, whose aldosteronemia had been evaluated after an equilibration period at controlled sodium intake at the occasion of previous studies, were retrospectively investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly wit...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199198
更新日期:1985-01-01 00:00:00
abstract::Jejuno-ileal bypass (JIB) and resection are associated with hyperplastic and other changes in residual functional gut. In studies on endocrine changes, circulating hormone levels are usually measured. In this study with Sprague-Dawley rats, glucagon, secretin and vasoactive intestinal polypeptide (VIP), immunoreactivi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199226
更新日期:1985-01-01 00:00:00
abstract::A 14C-triolein breath test was carried out on 49 subjects suffering from chronic pancreatitis or from other digestive diseases, and its results were compared with the daily fecal fat excretion. The 14CO2 peak excretion was abnormal in all the subjects with a fecal fat excretion above 14 g/day, whereas individual value...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199015
更新日期:1984-01-01 00:00:00
abstract::The diagnostic value of serum ferritin levels was evaluated in 19 patients with biopsy-proven primary hepatocellular carcinoma (PHC) and 26 patients with chronic liver disease (CLD). Serum ferritin levels were significantly elevated in PHC, as compared with CLD and controls (p less than 0.0005). Similarly, serum ferri...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199114
更新日期:1984-01-01 00:00:00
abstract::Mortality data for ulcerative colitis, Crohn's disease, and unspecified inflammatory bowel disease were examined for the countries Venezuela, Italy, and France during the decade 1969-1978. These figures were compared with similar data from England and Wales obtained from 1965 to 1975. In Italy and France deaths from C...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199040
更新日期:1984-01-01 00:00:00
abstract::The effect of human leukocyte interferon (IFN) on natural killer (NK) activity in 7 patients with HBsAg-positive chronic active hepatitis was investigated. Human leukocyte IFN was intramuscularly given once a week for 4 consecutive weeks (10 X 10(5), 5 X 10(5), 2 X 10(5) and 1 X 10(5) U). 1 week after the initial inje...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199107
更新日期:1984-01-01 00:00:00
abstract::Net fluid movement and mucosal 14C-erythritol clearance were measured in ligated colonic loops of the rat in vivo. The diphenolic laxatives, oxyphenisatin and bisacodyl, dose-dependently inhibited net fluid absorption or caused secretion, both increased the 14C-erythritol clearance. Pretreatment with the adenylate cyc...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199105
更新日期:1984-01-01 00:00:00
abstract::This study examined the morphological and functional adaptations occurring in the jejunum of adult rats fed totally by parenteral nutrition during a 4-day period. Comparison was made with sham-operated animals receiving orally a similar isocaloric diet. The intravenously fed rats exhibited a 20% shortening of the vill...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199030
更新日期:1984-01-01 00:00:00
abstract::The basal (interdigestive) gastrointestinal motor activity and the interdigestive gastric acid and pancreatic amylase secretion were determined in 10 young smokers (mean age 23 years) and 7 nonsmokers (mean age 26 years). There was no significant difference in the length of the interdigestive motor complex between smo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199018
更新日期:1984-01-01 00:00:00
abstract::Germ-free and conventional rats were fed a semi-synthetic diet including 10% wheat bran for 1 month. They were compared to similar rats fed the same diet without bran. Transit of polyethylene glycol (PEG) 4000 was studied in giving the marker either in saline or in the diet. The presence of a bacterial flora was found...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199006
更新日期:1984-01-01 00:00:00
abstract::In order to study some of the molecular events during the hepatic passage of gastrin, we perfused sulfated natural porcine gastrin (G17 II) through isolated pig livers. The disappearance half time of G17 II was about 20-30 min when the starting gastrin concentrations were greater than 100 pM; lower concentrations were...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199029
更新日期:1984-01-01 00:00:00
abstract::A statistical study was carried out to determine if fasting serum bile acid levels are clinically useful in differentiating children with chronic persistent hepatitis from children with chronic aggressive hepatitis. Serum bile acid levels were determined in 27 patients with chronic aggressive hepatitis, 41 with chroni...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198934
更新日期:1983-01-01 00:00:00
abstract::A manometric study of the distal biliary tract was carried out by means of a side-hole perfused catheter passed through the papilla Vateri during duodenoscopy in patients with postcholecystectomy biliary pain not due to stones or inflammation of the biliary tree. The sphincter of Oddi showed in these cases a significa...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198979
更新日期:1983-01-01 00:00:00
abstract::This study was designed to determine the influence of acetazolamide, a potent inhibitor of carbonic anhydrase, on the formation of gastric mucosal lesions induced by acidified aspirin (ASA) or absolute ethanol and on gastric cytoprotection induced by prostaglandin E2 (PGE2). Acetazolamide prevented dose-dependently et...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198975
更新日期:1983-01-01 00:00:00
abstract::The elimination kinetics of antipyrine have been established under basal environmental conditions in 6 healthy volunteers. Concentrations of antipyrine in serum were measured by a relatively fast high-pressure liquid chromatography method using a radial-compression chromatographic system. Pretreatment of the subjects ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198918
更新日期:1983-01-01 00:00:00